Multiple crashes in UnityAppController+Rendering.mm line 249, built with Unity 5.4.3p2 - p4

We're seeing a high number of crashes in our latest releases of one of our games. It seems to only be affecting iPhones so far, no iPads yet (which is the platform mostly used for our game), and so far we're only seeing crashes on iOS 10 no other versions, see the attached screen dump over devices and iOS versions. I've also attached the full log from crashlytics.

The crash seems to happen at UnityRepaint (UnityAppController+Rendering.mm:249), and it causes a Fatal Exception:...

Multiple crashes in UnityAppController+Rendering.mm line 249, built with Unity 5.4.3p2 - p4